Protection by melanin depends on its subcellular location.Although most filamentous fungi synthesize melanin via a polyketide synthase pathway, where and how melanin biosynthesis occurs and how it is deposited as extracellular granules remain elusive.Using a forward genetic screen in the pathogen Aspergillus fumigatus, we find that mutations in an
Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state.Here, Spa Masks we investigated the impact of Roux-en-Y gastric bypass (RYGB) surgery on postprandial VLDL1 and VLDL2 apoB and TG kinetics and their relationship wi
The Western Sahara issue is the most recent, lasting and unresolved case of decolonization in African continent, in the midst of the 21st Century.It is a non- governed territory, located in the northwest portion of Saharan Africa and it has been under UN custody since 1991, when MINURSO had been established.In this regard, this article has as main
Abstract Background Peptidergic neurons containing the melanin-concentrating hormone (MCH) and the hypocretins (or orexins) are intermingled in the zona incerta, perifornical nucleus and lateral hypothalamic area.Both types of neurons have been implicated in the integrated regulation of energy homeostasis and body weight.Hypocretin neurons have als
RNA silencing is directly involved in antiviral defense in a wide variety of eukaryotic organisms, including plants, fungi, invertebrates, and presumably vertebrate animals.The study of RNA silencing-mediated antiviral defences in vertebrates is hampered by the overlap with other antiviral mechanisms; thus, heterologous systems are often used to st